Related Experiment Video
Updated: Mar 27, 2026
Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients
Published on: March 29, 2022
Ocular biometric profile and clinical characteristics of high myopia in Indian children
Hardik Nanavati1, Jenil Sheth1, Ujjwal Kadu2
1Department of Pediatrics, Strabismus and Neuro-Ophthalmology, Shantilal Shanghvi Eye Institute, Mumbai, Maharashtra, India.
Insights
High myopia in Indian children involves early axial elongation and severe refractive error. Axial length is the primary driver, with other biometric factors offering predictive value for myopia progression.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Biometry
Background:
- High myopia is a significant global health concern, particularly in pediatric populations.
- Understanding ocular biometric parameters is crucial for managing myopia progression and associated complications.
Purpose of the Study:
- To profile ocular biometric parameters and clinical features in Indian children diagnosed with high myopia.
- To investigate the determinants of high myopia in a pediatric cohort.
Main Methods:
- Retrospective chart review of 123 Indian children (≤16 years) with high myopia (spherical equivalent [SE] ≤ -6.00 D).
- Analysis included cycloplegic refraction, axial length (AL), keratometry (K), anterior chamber depth (ACD), and lens thickness (LT).
- Pearson's correlation and multiple linear regression were used to assess correlations between SE and biometric variables.
Main Results:
- Mean SE was -9.84 ± 2.77 D and mean AL was 26.39 ± 1.39 mm.
- Strong correlation found between SE and AL (r = -0.777, P < 0.001); moderate correlation with LT (r = -0.281, P = 0.001).
- Retinal changes observed in 32.5% of eyes, with fundus abnormalities in all eyes having AL >28 mm.
Conclusions:
- High myopia in Indian children is marked by early axial elongation and severe refractive error.
- Axial length is the primary determinant of high myopia, with K, LT, and ACD providing additional predictive value.
- Early detection of retinal changes is vital in pediatric high myopia.
Purpose:
To profile ocular biometric parameters and clinical features in Indian children with high myopia.
Methods:
We conducted a retrospective chart review of electronic medical records at a tertiary care center from September 2023 to March 2025. Children ≤16 years with high myopia (spherical equivalent [SE] ≤ -6.00 D) and complete biometric data were included. Cycloplegic refraction, axial length (AL), keratometry (K), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness, and clinical findings of one eye per patient (left eye by convention) were extracted and analyzed. Correlations between SE and biometric variables were assessed using Pearson's correlation and multiple linear regression.
Results:
A total of 123 eyes from 123 patients (mean age 11.2 ± 3.5 years; 53% male) were analyzed. Mean SE was -9.84 ± 2.77 D (range -6.0 to -18.9 D), and mean AL was 26.39 ± 1.39 mm (range 23.75-30.46 mm). SE showed a strong correlation with AL (r = -0.777, P < 0.001) and a moderate correlation with LT (r = -0.281, P = 0.001) but a negligible association with K. Multiple regression incorporating AL, K, ACD, and LT explained 70.8% of SE variance (adjusted R² = 0.789, P < 0.0001). Retinal changes were present in 32.5% of eyes, most commonly tessellated fundus (29%), and all eyes with AL >28 mm showed fundus abnormalities.
Conclusion:
High myopia in Indian children is characterized by early axial elongation, severe refractive error, and early retinal changes. Axial length remains the principal determinant of myopia, though keratometry, lens thickness, and ACD provide additional predictive value.
More Related Videos
Related Concept Videos
01:25Glaucoma: Overview
01:16Focusing of Light in the Eye
01:27Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...