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Updated: Mar 27, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Visible-Light Induced Dehydrogenative Cross-Coupling of Enamides with Hydrocarbons Enabled by Aryl Thianthrenium Salt
Jian Han1,2,3, Qiu-Ru Zhang1, Yi-Lin Wang1
1School of Pharmacy, Changzhou University, Changzhou 213164, China.
Abstract:
Herein, we present a photocatalytic β-C(sp2)-H alkylation of enamides with easily accessible hydrocarbons under mild conditions. The utilization of aryl thianthrenium salt as a hydrogen-atom transfer (HAT) precursor enables the smooth generation of diverse carbon-centered radicals from chemical feedstocks containing hydridic or protic C-H bonds. Noteworthy features of this protocol encompass high step efficiency, good functional group compatibility, and excellent chemo-, regio-, and stereoselectivity. Mechanistic experiments and density functional theory (DFT) calculations support the involvement of an electron donor-acceptor (EDA) complex.
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