Research Progress on the Role of Basolateral Amygdala in Sleep and Anesthesia-Induced Alterations in Consciousness

Basolateral amygdala(BLA),an important component of the amygdala,has become a key region in the study of the regulation of anesthesia and the sleep-wake cycle in recent years.In addition to the role in the regulation of emotions and behaviors,BLA regulates the depth of anesthesia and affects the recovery from anesthesia through the interactions of a variety of neurotransmitters and neural circuits.Moreover,BLA mediates the transition of the sleep-wake state to affect the sleep duration.It has been demonstrated that BLA plays an extremely important role in the neurobiological mechanisms of anesthesia and sleep.This paper reviews the recent research progress in the roles of BLA in anesthesia and sleep-wake regulation,aiming to provide a new perspective for deeply understanding the function of BLA and offer a potential theoretical basis for improving clinical anesthetic outcome and sleep quality.