Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 27, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

10.5K

Research Progress on Adriamycin-Induced Myocardial Injury: Pathological Mechanism and Animal Model.

Xuan-Yi Tao1, Fang-Fang Xu1, Qi-Rui Shen2

  • 1Department of Pharmacy, Shanghai Tenth People's Hospital,Tongji University School of Medicine, Shanghai 200072, China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|March 26, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise suppresses IP6K3 to modulate BCAA metabolism and ferroptosis in MASLD.

Cellular & molecular biology letters·2026
Same author

Numerical investigation on the impact of solitary waves with variable incidence angles on offshore box-girder bridges.

Scientific reports·2026
Same author

Automated detection of defective coffee beans based on improved YOLOv10 framework.

Current research in food science·2026
Same author

Advances and Prospects of ZIF-Based Nanoplatforms for Therapeutic and Diagnosis Strategies in Endocrine Diseases.

ACS applied bio materials·2026
Same author

Booster vaccine reduces BCG-primed mice's protection against primary Mycobacterium tuberculosis infection by raising IL-10 levels.

Vaccine·2026
Same author

Synthesis and Structure-Property Relationships of 5/8/5 Fused Tricyclic Energetic Materials Via Triazinane-to-Tetrazocane Skeleton Transformation.

Organic letters·2026

Adriamycin chemotherapy can cause heart damage by harming myocardial cells, potentially leading to heart failure. This review covers mechanisms, treatments, and models for adriamycin-induced myocardial injury.

Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Adriamycin (doxorubicin) is a vital chemotherapy agent.
  • Adriamycin-induced cardiotoxicity damages myocardial cells, risking heart failure.
  • Understanding this injury is crucial for cancer patient care.

Purpose of the Study:

  • To review recent advances in adriamycin-induced myocardial injury.
  • To explore pathological mechanisms, therapeutic drugs, and animal models.
  • To inform research and develop effective treatments.

Main Methods:

  • Literature review of recent studies on adriamycin cardiotoxicity.
  • Analysis of pathological mechanisms of myocardial cell damage.
  • Evaluation of potential therapeutic interventions.
Keywords:
adriamycinanimal modelcurrent therapiesmyocardial injurypathological feature

More Related Videos

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
08:38

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

29.9K
Acute Myocardial Infarction in Rats
07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

55.0K

Related Experiment Videos

Last Updated: Mar 27, 2026

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
08:09

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

10.5K
Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
08:38

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

29.9K
Acute Myocardial Infarction in Rats
07:45

Acute Myocardial Infarction in Rats

Published on: February 16, 2011

55.0K
  • Assessment of commonly used animal models for research.

    • Main Results:

    • Adriamycin causes oxidative stress, mitochondrial dysfunction, and inflammation in myocardial cells.
    • Several therapeutic strategies, including antioxidants and specific inhibitors, show promise.
    • Various animal models (e.g., rodents, canines) are utilized to study the injury.

    Conclusions:

    • Adriamycin-induced myocardial injury is a significant clinical concern.
    • Further research into mechanisms and targeted therapies is essential.
    • Effective management strategies are needed to mitigate cardiotoxicity in cancer patients.