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Updated: Mar 27, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Programmed Oxidation-Guided Divergent Total Syntheses of (±)-Anisatin, (±)-Neoanisatin, (±)-Majusanols A and B
Juan Huang1, Xiaolan Wei1, Ziling Chen1
1State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 South Tianshui Road, Lanzhou, Gansu Province 730000, China.
Abstract:
The synthesis of complex, highly oxidized terpenes remains a central challenge, particularly when oxidation state dictates skeletal architecture. We establish a programmed oxidation strategy that prioritizes oxygen installation by its role in skeletal construction. This logic enabled the first total syntheses of neoanisatin (20 steps), majusanol A (18 steps), and majusanol B (19 steps), and delivered a significantly shorter route to anisatin (20 steps vs prior 40- and 43-step syntheses). Our work provides a generalizable design principle for the efficient and divergent synthesis of skeletally diverse, densely oxidized molecules.
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