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Cardiotrophin-1 as a mediator between systolic blood pressure and left ventricular hypertrophy in obesity
Chin-Feng Hsuan1,2,3, Jou-Wei Lin4,5, Thung-Lip Lee2,6
1Division of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, I-Shou University.
Insights
Cardiotrophin-1 (CT-1) mediates the link between blood pressure and left ventricular mass in severe obesity. This cytokine may serve as a biomarker or therapeutic target for obesity-related left ventricular hypertrophy.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Obesity Research
Background:
- Left ventricular hypertrophy (LVH) is common in obesity.
- The role of Cardiotrophin-1 (CT-1) in obesity-associated LVH is not well understood.
Purpose of the Study:
- To investigate whether CT-1 mediates the association between systolic blood pressure (BP) and left ventricular (LV) mass index in individuals with severe obesity.
Main Methods:
- Seventy-three adults with a body mass index (BMI) ≥35 kg/m2 were evaluated.
- Measurements included clinical assessment, echocardiography, and serum CT-1 levels.
- Mediation analysis was performed to assess the role of CT-1.
Main Results:
- LV mass index correlated with BMI and systolic BP.
- CT-1 levels correlated with systolic BP and LV mass index.
- CT-1 fully mediated the association between systolic BP and LV mass index.
Conclusions:
- CT-1 plays a mediating role in the effect of blood pressure on LV mass in severe obesity.
- CT-1 may represent a potential biomarker or therapeutic target for obesity-associated LVH.
Aims:
Left ventricular hypertrophy (LVH) is prevalent in obesity. Cardiotrophin-1 (CT-1), an interleukin-6 family cytokine implicated in myocardial remodeling, has an unclear role in obesity-associated LVH. This study examined whether CT-1 mediates the association between systolic blood pressure (BP) and left ventricular (LV) mass index in obesity.
Methods:
Seventy-three adults with body mass index (BMI) ≥35 kg/m 2 underwent clinical evaluation, echocardiography, and serum CT-1 measurement. Mediation analysis was performed using SPSS PROCESS macro (Model 4), with systolic BP as the independent variable, CT-1 as the mediator, and LV mass index as the dependent variable, adjusting for age, sex, and BMI.
Results:
Mean BMI, systolic BP, LV mass index, and CT-1 level were 42.4 ± 5.7 kg/m 2 , 146 ± 15 mmHg, 50.7 ± 11.8 g/m 2.7 , and 283.07 ± 632.94 pg/ml, respectively. LV mass index correlated with BMI ( r = 0.533, P < 0.001) and systolic BP ( r = 0.267, P = 0.022). CT-1 correlated with systolic BP ( r = 0.300, P = 0.010) and LV mass index ( r = 0.325, P = 0.005), but not BMI. Mediation analysis showed CT-1 fully mediated the systolic BP-LV mass index association, with a significant indirect effect ( B = 0.070, 95% CI [0.007, 0.168]) and a non-significant direct effect ( B = -0.042, P = 0.600, 95% CI [-0.201, 0.117]).
Conclusion:
CT-1 mediates the effect of BP on LV mass in severe obesity, suggesting that CT-1 may be a biomarker or therapeutic target in obesity-associated LVH.
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