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Comprehensive Genomic and Transcriptomic Analysis to Guide Therapy for Patients with Metastatic Solid Tumors.

Burak Uzunparmak1, Fei Su2, Amber Johnson3

  • 1The University of Texas MD Anderson Cancer Center Houston, Texas United States.

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|March 26, 2026
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Summary
This summary is machine-generated.

Comprehensive genomic and transcriptomic profiling (CGTP) using whole exome sequencing (WES) and whole transcriptome sequencing (WTS) shows significant clinical utility in advanced cancer patients. CGTP identified actionable alterations in most cases, enabling targeted therapy selection.

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • The clinical utility of comprehensive genomic and transcriptomic profiling (CGTP) compared to targeted panels is not well-defined for cancer patients.
  • Advanced or metastatic solid tumors often lack actionable targets identified by conventional sequencing methods.

Purpose of the Study:

  • To prospectively evaluate the clinical utility of CGTP, integrating whole exome sequencing (WES) and whole transcriptome sequencing (WTS).
  • To assess the identification of actionable genomic and transcriptomic alterations in patients with advanced cancers who had prior negative targeted panel sequencing.

Main Methods:

  • Prospective clinical study involving 99 patients with advanced solid tumors across 19 types.
  • Performed WES and WTS on patients with prior targeted panel sequencing and no identified biomarker-matched therapies.
  • Analyzed CGTP data for actionable DNA alterations and RNA expressions linked to approved or investigational agents.

Main Results:

  • CGTP identified actionable genomic alterations in 69.7% of patients.
  • Actionable transcriptomic alterations were identified in 100% of patients.
  • 19.2% of patients received biomarker-matched therapy in this pilot study integrating CGTP into routine care.

Conclusions:

  • CGTP demonstrates significant potential clinical utility in advanced cancer patients, revealing actionable targets missed by targeted panels.
  • Integrating WES and WTS provides a comprehensive molecular profile, increasing opportunities for biomarker-matched therapies.
  • Further studies are warranted to confirm the impact of CGTP on patient outcomes in routine clinical practice.