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Related Concept Videos

CRISPR and crRNAs02:53

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Updated: Mar 27, 2026

CRISPR/Cas12a Multiplex Genome Editing of Saccharomyces cerevisiae and the Creation of Yeast Pixel Art
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Delivering a multi-color, cell-based CRISPR experience to low-resource classrooms.

Andrew J Walters1,2, Alexander T Lyons1, Andrew A Williams1

  • 1Department of Chemistry and Biochemistry, Utah State University, Logan, Utah, USA.

Journal of Microbiology & Biology Education
|March 26, 2026
PubMed
Summary

This study introduces a low-cost, cell-based CRISPR educational tool for classrooms. This biotechnology empowers students with hands-on CRISPR system biology and technology experience, overcoming resource barriers.

Keywords:
CRISPRbiotechnologyeducationfluorescent proteinsimmune systemslow-resourcemicrobiologyrecombinant-protein productiontransformation

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics Education

Background:

  • CRISPR technologies are powerful tools in medicine, agriculture, and research.
  • Effective CRISPR education is crucial for public understanding of its benefits and limitations.
  • High costs and infrastructure needs limit access to CRISPR educational experiences in low-resource settings.

Purpose of the Study:

  • To develop an accessible, low-resource educational tool for teaching CRISPR biology and biotechnology.
  • To provide hands-on CRISPR-based learning experiences for high school and undergraduate students.

Main Methods:

  • Development of a multicolor, cell-based CRISPR assay.
  • Designed for deployment in high school and undergraduate classrooms.
  • Minimal resource requirements and simplified experimental procedures.

Main Results:

  • The developed assay provides a hands-on educational experience in CRISPR technology.
  • Successfully overcomes common barriers like cost and infrastructure.
  • Enables access for previously unserved and underserved student populations.

Conclusions:

  • The cell-based CRISPR educational tool effectively addresses accessibility issues in science education.
  • Facilitates broader understanding and engagement with CRISPR biotechnology among students.
  • Promotes equitable access to cutting-edge biotechnological education.