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Related Experiment Video

Updated: Mar 28, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

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Published on: October 4, 2024

Comparison of the modeling effects between two hemorrhoid models.

H Sun^1,2, W Xu^1,2, J Gao^3,4

¹Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, 050000, Hebei, China.

Techniques in Coloproctology

|March 26, 2026

Summary

A new rat internal hemorrhoid model better mimics clinical symptoms than the croton oil method. This improved model offers greater utility for developing new hemorrhoid treatments.

Keywords:

Animal model Hemorrhoid Hemorrhoid model comparative evaluation Model comparison

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Last Updated: Mar 28, 2026

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Published on: July 12, 2024

Area of Science:

Biomedical Research
Animal Models
Gastroenterology

Background:

Hemorrhoids are a common condition requiring effective treatment models.
Existing models may not fully replicate human hemorrhoid pathology.

Purpose of the Study:

To compare the efficacy of a novel rat internal hemorrhoid model against a standard croton oil-induced model.
To determine which model better reflects clinical hemorrhoid features for research.

Main Methods:

48 rats were divided into control and model groups.
A novel model combined croton oil with specific posture and movement; the control used croton oil alone.
Evaluations included clinical signs, anorectal coefficient, histopathology, laser speckle imaging, RT-qPCR, IHC, and Western blotting.

Main Results:

The novel model showed increased swelling, rectal prolapse, and anorectal coefficient compared to controls.
Histopathology revealed significant cell death and vascular congestion in the novel model.
Increased rectal blood perfusion, elevated pro-inflammatory cytokine mRNA (IL-2, IL-6, TNFα), and protein levels were observed in the novel model.

Conclusions:

The novel rat internal hemorrhoid model more accurately reflects clinical hemorrhoid characteristics.
This model is superior for preclinical research and the development of hemorrhoid therapies.