Related Experiment Video
Updated: Mar 28, 2026
07:15
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
10.6K
Precision probiotics for overweight management: decoding strain-specific mechanisms to guide microbiota-tailored
Sen Li1, Yao Lu1, Qianqian Wang1
1School of Health Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai, 200093, China. gnxo@163.com.
Food & Function
|March 26, 2026
Summary
Gut microbiota composition varies significantly, impacting probiotic effectiveness for obesity. Personalized probiotic strategies are needed to manage weight and metabolic disorders effectively.
Area of Science:
- Microbiology
- Metabolic Disorders
- Gut Microbiome Research
Background:
- Global obesity epidemic necessitates effective interventions.
- Gut microbiota heterogeneity influences probiotic efficacy.
- Dysbiosis is linked to metabolic disorders across diverse populations.
Purpose of the Study:
- To systematically review gut dysbiosis features in overweight populations.
- To elucidate mechanisms of probiotic action on metabolism.
- To advocate for precision probiotic interventions.
Main Methods:
- Systematic literature review of gut dysbiosis and probiotics.
- Analysis of molecular mechanisms of probiotic action.
- Examination of microbiota heterogeneity in overweight individuals.
Main Results:
- Gut dysbiosis presents distinct features across pediatric, pregnant, elderly, and adult overweight populations.
- Microbiota heterogeneity is a key factor in variable probiotic study outcomes.
- Probiotics modulate lipid metabolism, glucose homeostasis, and cellular stress.
Conclusions:
- Precision probiotic interventions can enhance management of overweight conditions.
- Understanding microbiota heterogeneity is crucial for clinical translation.
- Targeting the gut microbiome offers a promising strategy for metabolic health.
More Related Videos
Related Concept Videos
01:22Probiotics
144
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
144
01:22Introduction to the Human Microbiota
46
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
46
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.0K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.0K
01:30Development of Human Microbiota
21
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
21
01:18Functions of the Gut Microbiota
29
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
29
01:27Microbiota of the Large Intestine
16
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
16