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Updated: Mar 28, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Elevated Inflammatory Burden Index Is Association With Increased Sarcopenia: A Population-Based Study.

Li Xiao1,2,3,4, Yunzhe Li5, Xiuyun Li6

  • 1Department of Rehabilitation Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi Province, 341000, People's Republic of China, gmu.cn.

Mediators of Inflammation
|March 26, 2026
PubMed
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Mediators of inflammation·2026

High inflammatory burden index (IBI) is linked to increased sarcopenia risk. This association shows nonlinear characteristics and may indicate inflammation

Area of Science:

  • Biomedical research
  • Chronic disease epidemiology
  • Aging and muscle health

Background:

  • The inflammatory burden index (IBI) indicates systemic inflammation and is linked to chronic diseases.
  • The relationship between IBI and sarcopenia, a condition of muscle mass reduction, remains unclear.

Purpose of the Study:

  • To investigate the association between the inflammatory burden index (IBI) and sarcopenia.
  • To explore the nonlinear characteristics of this association.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2015-2018.
  • Calculated IBI using C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR).
  • Defined sarcopenia using skeletal muscle mass index (ASM/BMI) and analyzed associations via logistic regression with nonlinear and subgroup analyses.
Keywords:
C-reactive proteinNHANESinflammatory burden indexneutrophil-to-lymphocyte ratiosarcopenia

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Main Results:

  • A positive association was found between higher IBI and increased sarcopenia risk.
  • The highest IBI group had a 1.94 times greater risk of sarcopenia.
  • Nonlinear analysis revealed a significant risk increase before an inflection point at IBI=2.38.

Conclusions:

  • A nonlinear positive association exists between IBI and sarcopenia.
  • Elevated inflammation, as indicated by IBI, may contribute to sarcopenia development.
  • IBI presents a potential target for future sarcopenia interventions.