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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Updated: Mar 28, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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STEAP4 Modulates Intestinal Barrier Dysfunction and Inflammatory Signaling Pathways in Ulcerative Colitis.

Shimeng Xu1, Peixian Chen, Xiang Shi

  • 1Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, 226001 Nantong, Jiangsu, China.

Shock (Augusta, Ga.)
|March 26, 2026
PubMed
Summary
This summary is machine-generated.

Six-transmembrane epithelial antigen of the prostate 4 (STEAP4) is upregulated in ulcerative colitis (UC). Reducing STEAP4 improves intestinal barrier function and reduces inflammation, suggesting STEAP4 as a therapeutic target for UC.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background:

  • Ulcerative colitis (UC) involves intestinal barrier dysfunction and chronic inflammation.
  • The precise mechanisms driving UC pathogenesis are not fully understood.
  • Six-transmembrane epithelial antigen of the prostate 4 (STEAP4), a metalloreductase involved in redox regulation, is a potential factor.

Purpose of the Study:

  • To investigate the role of STEAP4 in the pathogenesis of ulcerative colitis.
  • To explore STEAP4's impact on intestinal barrier integrity and inflammatory responses.

Main Methods:

  • Analysis of clinical samples from IBD patients.
  • Utilized a dextran sulfate sodium (DSS)-induced murine colitis model.
  • Employed lipopolysaccharide (LPS)-treated intestinal epithelial cell lines (NCM460, HT-29).
  • Performed H&E staining, Western blot, and siRNA-mediated STEAP4 knockdown.

Main Results:

  • STEAP4 expression was significantly elevated in inflamed mucosa from human, murine, and in vitro models.
  • STEAP4 knockdown restored tight junction protein claudin-1, increased TEER, and decreased permeability.
  • STEAP4 suppression attenuated LPS-induced pro-inflammatory cytokines (TNF-α, IL-6) by inhibiting NF-κB phosphorylation.

Conclusions:

  • STEAP4 is a critical regulator of mucosal inflammation in UC.
  • STEAP4 links redox homeostasis, epithelial barrier function, and NF-κB signaling.
  • STEAP4 represents a potential therapeutic target for restoring intestinal homeostasis in UC.