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Updated: Mar 28, 2026
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Microstructural analysis of PLGA-PEG-PLGA copolymer based on NMR spectroscopy using model compounds
Bartosz Strus1, Jerzy Sitkowski2, Arkadiusz Szterk1
1ASLAB Science, Fort Służew 1/9, Warsaw 02-787, Poland; Chair of Preclinical Sciences, Department of Pharmacology and Toxicology, Warsaw University of Life Sciences, Nowoursynowska 166, Warsaw 02-787, Poland.
Abstract:
This study presents a novel strategy for studying the microstructure of PLGA-PEG-PLGA triblock copolymers synthesized via the ROP mechanism using various organic catalysts. The use of model copolymers (PLG-PEG-PLG, PLA-PEG-PLA) and multidimensional NMR spectroscopy (HSQC, HMBC, DOSY) enabled a more comprehensive characterization of the structure of PLGA-PEG-PLGA copolymers. The new method was verified by comparing the average molecular weights with the reference method-gel permeation chromatography. NMR analysis demonstrated a close correlation between the type of catalyst used, the monomer sequence arrangement, and the average molecular weights. The Zn(acac)₂ and Fe(acac)₃ catalysts demonstrated similar activity to the commonly used Sn(Oct)₂, making them potential substitutes in the synthesis of PLGA-PEG-PLGA copolymers. The proposed methodology provides detailed insight into copolymer microstructure, enabling more precise design of copolymers, which is essential for optimizing drug delivery systems.
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