A United Kingdom Value Set for the EQ-5D-5L.

Area of Science:

• Health Economics
• Psychometrics
• Social Sciences

Background:

• A UK-specific EQ-5D-5L value set is essential for health technology assessments, particularly for submissions to NICE.
• The EQ-5D-5L is the latest version of the widely used EQ-5D instrument.

Purpose of the Study:

• To generate a UK EQ-5D-5L value set using preference data.
• To ensure the value set is suitable for informing health policy and NICE assessments.

Main Methods:

• Data collected via composite time trade-off (TTO) interviews with a representative UK adult sample.
• 1200 interviews conducted, primarily via videoconference, covering 102 health states.
• Data quality rigorously assessed; TTO values requiring reconsideration were excluded. A random effects Tobit model was used for value set generation.

Main Results:

• High-quality data achieved from a representative sample across the UK.
• The generated value set indicates that anxiety/depression and usual activities dimensions have a greater impact on utilities compared to the UK EQ-5D-3L.
• The worst health state value is comparable to the UK EQ-5D-3L.

Conclusions:

• The study successfully generated a high-quality UK EQ-5D-5L value set.
• The value set is derived from appropriate and transparent data modelling.
• The generated value set is suitable for informing UK health policy and decision-making.