Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

648
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
648
Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

7.3K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
7.3K
Dose Response Curve: Conventional Versus Nonmonotonic01:21

Dose Response Curve: Conventional Versus Nonmonotonic

236
The correlation between a drug's dosage and its impact on a biological system is a cornerstone of pharmacology and toxicology. Conventional dose–response curves, which include graded and quantal relationships, are key to this understanding. Graded dose–response curves depict the spectrum of a biological reaction to different doses within an individual, indicating that as the drug dosage increases, so does the intensity of the response. On the other hand, quantal dose–response...
236
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

150
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
150
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

7.4K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
7.4K
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

289
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
289

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Provider attitudes, practices, and barriers in alcohol-associated liver disease care: Findings from the CASL ALD SIG national survey.

Canadian liver journal·2026
Same author

Public perspectives on supervised consumption sites across Canada: A cross-sectional study.

The International journal on drug policy·2026
Same author

"We're here, and we're non-judgmental, we're here to save lives": stressors and fulfillment among overdose response hotline operators in Canada.

Harm reduction journal·2026
Same author

Community-Based Co-Design of Public Health Messaging for Harm Reduction and Overdose Response Technology.

Health promotion practice·2026
Same author

Investigating the barriers to uptake and utilization of overdose response hotlines and apps: A study based on data from a national survey.

Digital health·2026
Same author

Perceived impacts of Supervised Consumption Sites (SCS) on key service aspects and settings: Reports from Canadian National Questionnaire on Overdose Monitoring (CNQOM).

The International journal on drug policy·2026

Related Experiment Video

Updated: Mar 28, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K

Cost-effectiveness analysis of Canada's National Overdose Response Service.

Will Rioux1, Ben Enns2, Dylan Viste3

  • 1Department of Medicine, University of Alberta, Edmonton, Alberta, Canada wjrioux@ualberta.ca.

BMJ Open
|March 26, 2026
PubMed
Summary

Canada's National Overdose Response Service (NORS) is a cost-effective strategy that saves lives and reduces overdose fatalities. This intervention offers significant population health benefits and mitigates risks associated with drug use.

Keywords:
HEALTH ECONOMICSPUBLIC HEALTHSubstance misuse

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.0K
Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

3.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.4K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

1.0K
Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
10:13

Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs

Published on: November 8, 2024

3.0K

Area of Science:

  • Public Health
  • Health Economics
  • Substance Use Research

Background:

  • Overdose deaths remain a critical public health issue in Canada.
  • Supervised consumption sites face closures, increasing the need for alternative harm reduction strategies.
  • Estimating the cost-effectiveness of overdose prevention services is crucial for resource allocation.

Purpose of the Study:

  • To evaluate the cost-effectiveness of Canada's National Overdose Response Service (NORS).
  • To identify conditions influencing the cost-effectiveness decision for NORS.
  • To assess the impact of overdose risk and program costs on NORS's cost-effectiveness.

Main Methods:

  • Retrospective cost-effectiveness analysis using a Markov cohort model.
  • Health sector perspective incorporating substance use, overdose, and mortality states.
  • Model calibration with Canadian overdose data and probabilistic sensitivity analyses.

Main Results:

  • NORS was found to be a dominant strategy over a lifetime, yielding additional QALYs and cost savings.
  • While not cost-effective in the first year, NORS became cost-effective beyond 5 years.
  • Key cost drivers included cost per NORS call and EMS call-out probability; NORS coverage and overdose risk influenced QALYs.

Conclusions:

  • NORS is a cost-effective and cost-saving intervention for reducing fatal overdose risk.
  • The service provides substantial population-level health benefits.
  • NORS presents a critical opportunity to mitigate overdose fatalities amidst policy shifts and service access challenges.