Related Experiment Video For dysplasia
Updated: Mar 28, 2026
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Malignant Transformation of Oral Epithelial Dysplasia in Southern Finland
Katariina Leino1, Hanna K Laine1, Ville Kinnula2
1Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Background:
Oral epithelial dysplasia (OED) often precedes oral squamous cell carcinoma (OSCC). The aim was to elucidate the risk and time of malignant transformation (MT) of OED.
Methods:
Patients diagnosed with OED between 2001 and 2011 in Helsinki and Uusimaa, Finland were included. Kaplan-Meier and Cox proportional hazard analysis factors associated with the MT time.
Results:
Dysplasias of 225 patients (mean age 60.0 years, 51.6% females) were diagnosed as mild (85.8%), moderate (11.6%), or severe (2.7%). MT occurred in 14.7% (51.5% females, 48.5% males) at a median time of 5.5 years (IQR 1.7-12.5 years). MT occurred in 33.3% of severe (n = 6), 34.6% (n = 26) of moderate, and 11.4% (n = 193) of mild dysplasia. Dysplasia severity was associated with an increased risk for MT.
Conclusions:
MT of OED was 14.7%. The severity of OED is a predictor for MT.
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