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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Compact Bone01:27

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Related Experiment Video

Updated: Mar 28, 2026

Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis
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Prediction of Osteoporosis and Fragility Fracture Risk Using Proximal Humerus CT Value from Chest CT: A Development

Chen-Xu Zhao1, Ren-An Wang2, Xiao Feng3

  • 1Department of Radiology, General Hospital of Northern Theater Command, Shenyang 110016, China (C-X.Z., M-Y.Z., X-G.L., D.H., B-Q.Y., Y.S., L-B.Z.); Dalian Medical University 967 Hospital of the Joint Logistics Support Force Graduate Training Base, Dalian, China (C-X.Z.).

Academic Radiology
|March 26, 2026
PubMed
Summary

A new nomogram using proximal humerus CT values from chest scans can screen for osteoporosis and fracture risk. This cost-effective method aids in early detection without extra radiation exposure.

Keywords:
Chest CTFragility fractureOpportunistic screeningOsteoporosisProximal humerus

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Area of Science:

  • Radiology
  • Osteoporosis Research
  • Medical Imaging Analysis

Background:

  • Osteoporosis diagnosis and fracture risk assessment often require specialized tests.
  • Routine chest CT scans present an opportunity for opportunistic screening.

Purpose of the Study:

  • To develop a nomogram integrating proximal humerus CT values from chest CT scans.
  • To enable opportunistic osteoporosis screening and fragility fracture risk assessment.
  • To provide a cost-effective and radiation-free screening tool.

Main Methods:

  • Retrospective multicenter study of 542 patients.
  • Development of a baseline clinical model.
  • Measurement of proximal humerus CT values from routine chest CT scans.
  • Construction of a combined Clinical + CT model using multivariable logistic regression.
  • Evaluation via ROC curve analysis, calibration curves, and decision curve analysis.

Main Results:

  • The Clinical + CT model significantly improved fracture risk prediction (AUC 0.922 training, 0.914 validation) and osteoporosis diagnosis (AUC 0.804 training, 0.800 validation) compared to the clinical model.
  • The model demonstrated high reliability and clinical utility.

Conclusions:

  • A nomogram combining clinical factors and proximal humerus CT values from routine chest CT scans is effective for opportunistic screening of osteoporosis and high fracture risk.
  • This integrated approach offers a simple, reliable, and cost-effective tool for early identification of at-risk individuals.
  • Decision curve analysis confirmed a significant net clinical benefit for both assessed endpoints.