Enhancing Diagnostic Precision in Malignant Hematological Disorders Through Risk Factor Analysis for High-Quality...

Area of Science:

• Hematology
• Oncology
• Diagnostic Pathology

Background:

• Bone marrow aspiration (BMA) diagnostic accuracy may be compromised by hematological malignancies.
• The impact of these conditions on BMA quality is not well-understood.

Purpose of the Study:

• To investigate the association between hematological malignancies and BMA quality.
• To identify patient-specific and laboratory risk factors influencing BMA quality.

Main Methods:

• Multivariable logistic regression analysis was employed.
• The study defined BMA quality as optimal or suboptimal.
• The analysis included 875 patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), multiple myeloma (MM), or non-Hodgkin lymphoma (NHL).

Main Results:

• Patients with AML and MDS showed a higher likelihood of suboptimal BMA.
• Advanced age was associated with suboptimal BMA in AML and MDS patients.
• Higher hemoglobin and platelet levels correlated with optimal BMA in these groups.

Conclusions:

• In AML and MDS, factors including advanced age and lower hemoglobin/platelet/white blood cell counts are associated with BMA quality.
• These factors can impact the diagnostic accuracy of bone marrow aspiration.