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Updated: Mar 28, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Methyl Formate Meets Water: Phosphine-Free Mn(I) Catalysis for Chemoselective Olefin & Carbonyl Hydrogenation
Divya Mahapatra1, Anirban Sau1, Sumit Ranjan Das1
1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India.
Abstract:
Employing 3d-metal hydrides in hydrogen-transfer catalysis with water as a supplementary reagent remains in its infancy. Herein, we report a phosphine-free Mn(I)-bisNHC system that mediates methyl formate dehydrogenation in water, enabling chemoselective transfer hydrogenation of olefinic bonds in diverse aryl acrylonitriles and phenyl enones and carbonyl groups in α,β-epoxy ketones. Combined experimental and DFT studies reveal base-assisted Mn-H formation from MF/H2O and substrate-driven electronic effects governing selectivity, establishing a robust platform for aqueous hydrogen-transfer transformations.
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