Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

44.0K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
44.0K
Parasympathetic Signaling01:30

Parasympathetic Signaling

4.0K
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
4.0K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.2K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of the locus coeruleus in giant migrating contractions of colonic motility in Suncus murinus.

Experimental brain research·2026
Same author

Motilin stimulates food intake linked to gastric motility in <i>Suncus murinus</i>: Simultaneous recordings of food intake and gastric motility in the conscious state.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Short Term Soft Pellet Diet Changes Intestinal Characteristics in Mice.

Journal of animal physiology and animal nutrition·2025
Same author

The role of free fatty acid receptor-1 in gastric contractions in <i>Suncus murinus</i>.

Food & function·2024
Same author

Involvement of the autonomic nervous system in colonic contractions in conscious Suncus murinus.

Neurogastroenterology and motility·2023
Same author

Diurnal changes of colonic motility and regulatory factors for colonic motility in Suncus murinus.

Neurogastroenterology and motility·2021

Related Experiment Video

Updated: Mar 28, 2026

Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
12:00

Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines

Published on: January 27, 2016

11.0K

Purinergic ATP-P2X7 Signaling Drives Colonic Giant Migrating Contraction in Suncus murinus.

Ayano Gomi1, Hozuki Shimosawa1, Ichiro Sakata1,2

  • 1Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|March 27, 2026
PubMed
Summary

Adenosine triphosphate (ATP) regulates giant migrating contractions (GMCs) in the colon by activating P2X7 receptors on cholinergic neurons. This finding offers a potential therapeutic target for colonic motility disorders.

Keywords:
ATPGMCcolonexperimental animal modelsgastrointestinal motilitymuscle contraction

More Related Videos

Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.7K
Studying Murine Small Bowel Mechanosensing of Luminal Particulates
10:21

Studying Murine Small Bowel Mechanosensing of Luminal Particulates

Published on: March 18, 2022

2.5K

Related Experiment Videos

Last Updated: Mar 28, 2026

Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
12:00

Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines

Published on: January 27, 2016

11.0K
Gastrointestinal Motility Monitor GIMM
08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.7K
Studying Murine Small Bowel Mechanosensing of Luminal Particulates
10:21

Studying Murine Small Bowel Mechanosensing of Luminal Particulates

Published on: March 18, 2022

2.5K

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Pharmacology

Background:

  • Giant migrating contractions (GMCs) are crucial for colonic content propulsion and defecation.
  • The precise regulatory mechanisms governing GMCs are not fully understood.

Purpose of the Study:

  • To identify factors regulating colonic GMC activity.
  • To elucidate the underlying mechanism of GMCs in vivo and in vitro.
  • To utilize the Suncus murinus model for studying colonic motility.

Main Methods:

  • Administered adenosine triphosphate (ATP) intravenously in conscious Suncus murinus.
  • Utilized P2X7 receptor antagonists and agonists to investigate ATP's role.
  • Examined colonic contractions in vivo and in vitro.
  • Assessed the effect of atropine on ATP-induced contractions.

Main Results:

  • Intravenous ATP induced GMC-like contractions in vivo.
  • P2X7 receptor antagonists significantly inhibited ATP-induced GMCs.
  • A P2X7 receptor agonist mimicked ATP's effect, inducing GMC-like contractions.
  • ATP-induced GMCs were attenuated by atropine, indicating cholinergic involvement.
  • ATP did not induce colonic contractions in vitro.

Conclusions:

  • Purinergic signaling via adenosine triphosphate (ATP) is a novel regulator of colonic GMCs.
  • ATP activates cholinergic neurons through P2X7 receptors to initiate colonic contractions.
  • Targeting ATP-mediated signaling pathways presents a potential therapeutic avenue for motility disorders.