Related Experiment Video
Updated: Mar 28, 2026

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
Published on: May 31, 2024
Advances in Biomolecular Condensates: From Disease Therapy to Synthetic Biology
Wenjun Xie1,2, Chaojuan Yang3, Mengqian Shi1
1State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China.
Abstract:
Biomolecular condensates (BMCs) are membraneless organelles (MLOs) formed by liquid-liquid phase separation (LLPS) of biomolecules such as proteins and nucleic acids (NAs). They are widely present in organisms and participate in key life processes such as gene transcription regulation. Its dynamic, environmental responsiveness and selective enrichment capabilities lay the foundation for biomedical and engineering biology applications and can be used as innovative targets for new drug research and disease treatment, for building bioreactors, and for developing intelligent biomaterials as well as delivery systems. At present, the related research is converted into various frontier applications, especially providing new intervention strategies for previously undruggable targets. This paper reviews the latest breakthroughs, technical challenges, and future directions from the perspective of frontier applications.
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
The Central Dogma
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Microorganisms in Medicine and Therapeutics

