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Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
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Spatially Defined DNA Origami Cell Engagers for T and Natural Killer Cell-Mediated Immune Modulation.
Yueyang Sun1, Liang Xu2, Yiying Qian1
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China.
ACS Nano
|March 27, 2026
Summary
This study introduces a DNA origami platform to precisely arrange antibodies, creating advanced cell engagers for cancer immunotherapy. These engineered immunotherapies effectively target tumors and enhance immune responses for better cancer treatment.
Area of Science:
- Biotechnology
- Immunology
- Nanotechnology
Background:
- Cell engagers are a key cancer immunotherapy strategy.
- Their effectiveness is limited by antibody structure and arrangement.
- Precise control over antibody presentation is needed to improve efficacy.
Purpose of the Study:
- To develop a DNA origami platform for precise spatial organization of antibodies.
- To engineer tailored multivalent cell engagers for enhanced antitumor immunity.
- To investigate the efficacy of T cell engagers and natural killer cell engagers.
Main Methods:
- Utilized DNA origami scaffolds for antibody spatial organization.
- Modulated antibody composition, valency, and arrangement at the single-molecule level.
- Developed and tested T cell and natural killer cell engagers against EGFR-expressing tumors.
Main Results:
- Engineered cell engagers demonstrated effective immune cell activation and tumor specificity.
- In vitro studies showed specific immune responses against EGFR-expressing tumors.
- In vivo studies confirmed tumor growth inhibition in murine models.
Conclusions:
- DNA origami is a versatile platform for engineering precision immunotherapies.
- The developed cell engagers show potential for targeted tumor eradication.
- This approach offers a programmable method to enhance cancer immunotherapy.
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