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Updated: Mar 28, 2026

Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Tailored Manganese-Catalyzed Enantioconvergent Hydrophosphination to Access Remote P,C-Stereogenic Phosphines
1Key Laboratory of Sustainable Low-carbon Technologies for Textile Dyeing and Finishing, Ministry of Education, State Key Laboratory of Advanced Fiber Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Abstract:
Achieving stereocontrol over two remote, flexible P- and C-stereocenters with a single catalyst remains a formidable challenge in the construction of chiral phosphines. We herein report a manganese-catalyzed enantioconvergent hydrophosphination of racemic allylic alcohols via a borrowing hydrogen (BH) strategy. This approach utilizes a single tailored Mn catalyst to orchestrate a cascade of dehydrogenation, enantioconvergent P-H addition, and asymmetric hydrogenation. This method provides direct access to P,C-stereogenic γ-hydroxy phosphines with excellent enantio- and diastereoselectivity, offering an atom-economical and sustainable route to diverse, high-value chiral phosphine libraries.
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