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Updated: Mar 28, 2026
Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Effects of a comprehensive management mode for overweight/obesity based on mobile internet technology and traditional
Xin Chen1,2, Junyi Duan3, Ruxin Duan4
1Department of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Background:
We aimed to investigate the overall effectiveness of a comprehensive management mode for overweight/obesity based on mobile internet technology and TCM constitution theory.
Methods:
40 subjects were enrolled and randomly divided into control group (traditional obesity management mode) and intervention group (comprehensive obesity management mode). The intervention period was 8 weeks, and the follow-up period was 1 year. The information of body indicators, blood indicators and gut microbiota indicators at baseline, 8 weeks and 1 year were collected and analyzed, the primary outcome was the effective weight loss (≥5% body weight loss) rate at 1 year.
Results:
The average age of 40 subjects was 40.3 ± 9.49 years old, with 18 males accounting for 45%. The effective weight loss rate of intervention group was significantly higher than control group (75% vs. 35%; p = 0.025) at 1 year. The body weight (6.88 ± 4.00 vs. 3.08 ± 2.35, p = 0.001), BMI(2.38 ± 1.23 vs. 1.10 ± 0.87, p = 0.001), body fat rate(BFR; 1.8 ± 0.85 vs. 0.82 ± 0.60, p = 0.001), fasting plasma glucose (FPG; 1.08 ± 0.69 vs. 0.49 ± 0.91, p = 0.027), total cholesterol (TC; 1.72 ± 0.60 vs. 0.77 ± 0.57, p = 0.001), Triglyceride (TG; 0.56 ± 0.52 vs. 0.16 ± 0.22, p = 0.003), low density lipoprotein cholesterol (LDL-C; 1.35 ± 0.49 vs. 0.71 ± 0.50, p = 0.001), and diastolic blood pressure (DBP; 1.80 ± 1.96 vs. 0.60 ± 1.57, p = 0.039) decreased more significant in the intervention group. The gut microbiota analysis showed that after intervention, in the intervention group, at phylum level, the Cyanobacteria abundance increased (p = 0.040), while the Euryarchaeota abundance decreased (p = 0.045). In addition, the functional abundance of Photosynthesis decreased (p = 0.008).
Conclusion:
The comprehensive overweight/obesity management mode integrating mHealth with TCM constitution showed more significant long-term weight loss effects. The increase of Cyanobacteria and decrease of Euryarchaeota may be associated with this effect, warranting further investigation.
Clinical Trial Registration:
https://www.chictr.org.cn/showproj.html?proj=43245, Identifier, ChiCTR1900025881.
