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Updated: Mar 28, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
A Total Synthesis of (-)-Strychnine Using Photoredox Catalysis
Rainer Wiechert1, Leander Geske1, Jasmin Hammes1
1Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany.
Abstract:
A concise route toward (-)-strychnine is presented. Key steps include the photoredox-catalytic C2-cyanomethylation of Boc-l-Trp-OMe and a condensation-electrocyclization cascade linking two fragments convergently to obtain an advanced intermediate. A photochemical decarboxylation provided convenient access to strychnofluorine, which could be transformed through the Wieland-Gumlich aldehyde to strychnine. All building blocks can be traced back to renewable sources.
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