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Updated: Mar 28, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

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Published on: August 3, 2018

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TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.

Chan Jin Park1, Pengfei Zhang1, Carolina Trenado-Yuste1,2

  • 1Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544.

Biorxiv : the Preprint Server for Biology
|March 27, 2026
PubMed
Summary

Branch spacing in developing lungs is regulated by transforming growth factor-beta (TGFβ) signaling to the mesenchyme. This signaling drives mesenchymal cell migration, which physically separates developing epithelial branches, ensuring efficient gas exchange.

Keywords:
mechanical stressmorphogentissue morphodynamics

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