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Expanding TheCellMap.org to visualize a genome-scale genetic interaction network for a human cell line
Ira Horecka1,2, Matej Ušaj2, Myra P D Masinas2
1Department of Molecular Genetics, University of Toronto; Toronto ON, M5S 3E1, Canada.
Biorxiv : the Preprint Server for Biology
|March 27, 2026
Summary
TheCellMap.org now includes ~89,000 human genetic interactions from CRISPR screens. This resource allows researchers to explore gene networks and functional relationships in HAP1 cells.
Area of Science:
- Genomics
- Systems Biology
- Bioinformatics
Background:
- Genetic interaction networks reveal gene functional relationships.
- TheCellMap.org previously hosted yeast genetic interaction data.
- Genome-scale genetic interaction data is crucial for understanding cellular pathways.
Purpose of the Study:
- To expand TheCellMap.org with human genetic interaction data.
- To provide a platform for exploring human gene networks.
- To enable visualization and analysis of large-scale genetic interaction datasets.
Main Methods:
- Genome-scale CRISPR-based screening was employed.
- Analysis of ~4 million human gene pairs in HAP1 cells.
- Development of interactive network visualization and sub-network extraction tools.
Main Results:
- Incorporation of ~89,000 quantitative human genetic interactions.
- TheCellMap.org now supports exploration of human HAP1 genetic interactions.
- New features for data-driven network layouts and interactive exploration.
Conclusions:
- The expanded TheCellMap.org is a valuable resource for human genetic interaction studies.
- The platform facilitates the discovery of gene functions and pathways.
- Interactive exploration of large genetic interaction networks is now more accessible.
