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Related Experiment Video

Updated: Mar 28, 2026

C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position

C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position

Published on: September 16, 2022

Multi-Omics Bioinformatic Analyses Linking LOXL4 with Spondylolisthesis.

Hui Wang^1,2, Peng Niu^2,3, Xiu Yang¹

¹Department of Orthopedics Surgery (Joint Surgery Ward), 900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian, People's Republic of China.

Orthopedic Research and Reviews

|March 27, 2026

Summary

This summary is machine-generated.

This study identifies LOXL4 as a key gene in spondylolisthesis progression using genetic analysis. Further research is needed to confirm its role and therapeutic potential in this spinal disorder.

Keywords:

LOXL4 Mendelian randomization eQTL estradiol mQTL omics analysis progesterone spondylolisthesis

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Last Updated: Mar 28, 2026

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Area of Science:

Genetics
Molecular Biology
Bioinformatics

Background:

Spondylolisthesis is a spinal disorder involving vertebral displacement, with its genetic underpinnings requiring further elucidation.
Understanding the genetic factors is crucial for developing effective therapeutic strategies for spondylolisthesis.

Purpose of the Study:

To identify key genes influencing the progression of spondylolisthesis.
To investigate the causal genetic associations between gene expression and methylation with spondylolisthesis.

Main Methods:

Summary-data-based Mendelian randomization (SMR) analysis was employed to assess eQTL and mQTL data.
Bayesian colocalization analysis identified candidate genes, followed by qRT-PCR validation.
Enrichment analysis, compound prediction, and molecular docking explored gene function and interactions.

Main Results:

SMR analysis revealed numerous cis-eQTLs and mQTLs associated with spondylolisthesis.
LOXL4 was identified as a key gene through Bayesian colocalization, showing strong eQTL and mQTL signals.
LOXL4 is linked to extracellular matrix integrity and potentially regulated by hormones like estradiol and progesterone.

Conclusions:

LOXL4 is proposed as a candidate gene involved in spondylolisthesis progression.
LOXL4 represents a potential therapeutic target for spondylolisthesis.
Further experimental validation is necessary to confirm the role of LOXL4 in spondylolisthesis.