Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Drugs that Stabilize Microtubules

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Interaction of bi-nuclear gallium(III) complexes with human serum albumin and impact on potency towards osteosarcoma stem cells.

Dalton transactions (Cambridge, England : 2003)·2026

Same author

Anti-breast cancer stem cell activity of titanocene complexes of non-steroidal anti-inflammatory drugs.

Dalton transactions (Cambridge, England : 2003)·2025

Same author

Osteosarcoma Cell and Osteosarcoma Stem Cell Potent Immunogenic Bi-Nuclear Gallium(III) Complexes.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025

Same author

The Anti-Cancer Stem Cell Properties of Copper(II)-Terpyridine Complexes with Attached Salicylaldehyde Moieties.

Chembiochem : a European journal of chemical biology·2024

Same author

An immunogenic anti-cancer stem cell bi-nuclear copper(II)-flufenamic acid complex.

Dalton transactions (Cambridge, England : 2003)·2024

Same author

H<sub>2</sub> O ⋅ B(C<sub>6</sub> F<sub>5</sub> )<sub>3</sub> -Catalyzed para-Alkylation of Anilines with Alkenes Applied to Late-Stage Functionalization of Non-Steroidal Anti-Inflammatory Drugs.

Chemistry (Weinheim an der Bergstrasse, Germany)·2024

Same journal

Steric Mapping, Ligand Dynamics, and Cycloisomerization Catalysis with Redox Robust Mn<sup>I/0/‑I</sup> Dicarbenes.

Organometallics·2026

Same journal

Imidazol-2-ylidene-Based NCCN Ligands for Chiral-at-Iron Catalysis.

Organometallics·2026

Same journal

Ni(DQ)<sub>2</sub>: A Useful Gateway to Zero-Valent Nickel Complexes.

Organometallics·2026

Same journal

Di-Silyl Rhodium(III) and Iridium(III) Complexes as Catalysts in Carbene Insertion Reactions into Hydrosilanes.

Organometallics·2026

Same journal

Isolation of Base-Coordinated 1,4-Disilaquinones.

Organometallics·2026

Same journal

Flash Communication: A Metal-First Approach to Ruthenium Complexes of a Boryl-Centered POBOP Pincer Ligand.

Organometallics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 28, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Cyclometalated Rhodium(III) Polypyridyl Complexes with Anti-Cancer Stem Cell Activity.

Hao Ren¹, Kuldip Singh¹, Kogularamanan Suntharalingam¹

¹School of Chemistry, University of Leicester, Leicester LE1 7RH, U.K.

Organometallics

|March 27, 2026

Summary

This summary is machine-generated.

New rhodium complexes show potent anticancer stem cell (CSC) activity. Complex 4 effectively targets breast and osteosarcoma CSCs, outperforming existing treatments.

More Related Videos

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

Published on: July 5, 2019

Related Experiment Videos

Last Updated: Mar 28, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

Published on: July 5, 2019

Area of Science:

Inorganic Chemistry
Medicinal Chemistry
Cancer Biology

Background:

Anticancer stem cells (CSCs) drive tumor growth and recurrence.
Rhodium complexes are largely unexplored for their CSC-targeting potential.

Purpose of the Study:

To synthesize and evaluate novel cyclometalated rhodium(III)-polypyridyl complexes for anticancer stem cell activity.
To investigate the structure-activity relationship of these complexes against various CSCs.

Main Methods:

Synthesis and characterization of four rhodium(III)-polypyridyl complexes.
In vitro evaluation of anti-CSC activity against breast and osteosarcoma stem cells using monolayer and 3D cultures.
Comparison of efficacy with cisplatin and salinomycin.

Main Results:

Complex 4, featuring a 4,7-diphenyl-1,10-phenanthroline ligand, demonstrated significant anti-CSC activity in the sub-micromolar to low micromolar range.
The rhodium(III) scaffold showed superior efficacy compared to cisplatin and salinomycin against both breast and osteosarcoma CSCs.
Photophysical properties were characterized, providing insights into potential mechanisms of action.

Conclusions:

The developed rhodium(III)-polypyridyl complexes represent a promising new class of agents targeting cancer stem cells.
The cyclometalated rhodium(III) scaffold, specifically with 2,2'-(phenylmethylene)-dipyridine, is a viable synthon for future anti-CSC drug development.
Further research into these complexes could lead to novel therapeutic strategies for overcoming chemoresistance and preventing cancer relapse.