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Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

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Microglia associated research in depression: an exploratory trends analysis.

Yan-Jun Chen^1,2, Qin-Quan Zhu¹, Ming-Rong Xie³

¹The First Hospital of Hunan University of Chinese Medicine, Changsha, China.

Frontiers in Aging Neuroscience

|March 27, 2026

Summary

This bibliometric analysis reveals a growing research focus on microglia and their role in depression. Key areas for future study include the kynurenine pathway, NF-κB signaling, and the gut microbiota.

Keywords:

depression gut microbiota kynurenine pathway microglia neuroinflammation

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Published on: September 6, 2024

Area of Science:

Neuroscience
Immunology
Psychiatry

Background:

Depression is a severe affective disorder with significant global impact.
Microglia, the immune cells of the central nervous system, are increasingly implicated in depression's progression.
Understanding the intricate relationship between microglia and depression is crucial for developing effective treatments.

Purpose of the Study:

To conduct a comprehensive bibliometric analysis of research on microglia in depression.
To identify key trends, influential publications, and emerging research hotspots in this field.
To elucidate the evolution of research and suggest future directions for microglia-depression studies.

Main Methods:

Systematic retrieval of 2,305 publications from Scopus and Web of Science databases (2001-2024).
Utilized CiteSpace, VOSviewer, and Bibliometrix software for visual bibliometric analysis.
Analyzed publication trends, country/institution contributions, prolific authors, and high-frequency keywords.

Main Results:

Research on microglia in depression shows a consistent upward trend from 2001 to 2024.
China leads in research output, with Nantong University and Dr. Huang Chao being highly productive.
Key research themes include neuroinflammation, hippocampus, metabolism, cytokines (e.g., IL-1β), and stress responses.

Conclusions:

Bibliometric analysis offers valuable insights into the field of microglia and depression.
International collaboration is advancing research in this area.
Neuroinflammation mediated by microglia is a central mechanism in depression, with the kynurenine pathway, NF-κB signaling, HPA axis, and gut microbiota as promising future research avenues.