Related Experiment Video
Updated: Mar 28, 2026
05:28
Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
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Progress on Potential Therapeutic Targets for Sepsis-Related Cardiac Dysfunction: From Basic Research to Clinical
Yan Gao1, Rui Dai1, Chang Kong1
1Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China.
Immunotargets and Therapy
|March 27, 2026
Summary
Sepsis-related cardiac dysfunction involves complex immune responses and cell death. Natural compounds like ginsenosides and melatonin show promise for multi-target therapies to improve patient outcomes.
Area of Science:
- Cardiology
- Immunology
- Pharmacology
Background:
- Sepsis-related cardiac dysfunction (SRCD) is a critical complication of sepsis.
- Its pathophysiology involves inflammation, immune cell dysfunction, and programmed cell death.
Purpose of the Study:
- To review the core pathophysiological mechanisms of SRCD.
- To evaluate multi-target therapeutic strategies, focusing on natural compounds.
Main Methods:
- Literature review of SRCD pathophysiology.
- Analysis of immune cell crosstalk (macrophages and neutrophils).
- Evaluation of natural compounds as therapeutic interventions.
Main Results:
- Immune cell crosstalk is central to SRCD.
- Natural compounds, such as ginsenosides and melatonin, demonstrate multi-target protective effects.
- These compounds offer promising therapeutic potential.
Conclusions:
- Understanding SRCD mechanisms is key for developing precise therapies.
- Natural compounds present viable options for multi-target treatment strategies.
- Further research integration is needed to improve patient survival and quality of life.
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