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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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ROS-Responsive Nano-Encapsulated Selenium Targeting Cervical Cancer Cell via PI3K/AKT Signaling Pathway.

Yanmei Qiu^1,2, Chongke Hu¹, Sifang Zhao³

¹Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuili Hospital of Ningbo University, Ningbo, Zhejiang, 315100, People's Republic of China.

International Journal of Nanomedicine

|March 27, 2026

Summary

This summary is machine-generated.

Targeted ROS-responsive selenium nanoparticles (FA-ReRSeNPs) offer improved cervical cancer treatment by reducing toxicity and enhancing efficacy. These nanoparticles effectively inhibit tumor growth and induce apoptosis, showing promise for advanced cancer therapy.

Keywords:

FA-ReRSeNPs FA-ReRSeNPslenium PI3K/AKT signaling pathway ROS-responsive delivery cervical cancer targeted therapy

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Published on: June 13, 2014

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Current cervical cancer treatments often suffer from significant off-target toxicity and inefficient drug delivery, limiting patient quality of life.
Selenium nanoparticles possess inherent anticancer properties but require optimized delivery systems to overcome these limitations.

Purpose of the Study:

To develop targeted ROS-responsive selenium nanoparticles (FA-ReRSeNPs) for enhanced cervical cancer therapy.
To overcome the challenges of off-target toxicity and inefficient delivery associated with conventional treatments.
To leverage selenium's anticancer properties through advanced nanoengineering.

Main Methods:

FA-ReRSeNPs were synthesized and characterized for physicochemical and biological properties.
In vitro assays using human cervical cancer cells (Hela and SiHa) and in vivo studies with a SiHa subcutaneous xenograft nude mouse model were employed.
Mechanistic studies investigated the anti-tumor activity and signaling pathways involved.

Main Results:

FA-ReRSeNPs significantly reduced the required selenium dose for anticancer activity while minimizing off-target damage to normal tissues.
Anticancer effects were achieved through the inhibition of the PI3K/AKT signaling pathway, leading to tumor cell apoptosis and proliferation restraint.
In vitro and in vivo analyses demonstrated superior tumor-inhibitory potential and high targeting specificity of FA-ReRSeNPs.

Conclusions:

FA-ReRSeNPs represent a precision-driven nanotherapeutic for cervical cancer management.
The combination of active targeting and ROS-responsive release addresses the efficacy-toxicity dilemma of conventional anticancer agents.
This study highlights the translational value of intelligent nanoengineering in advancing cancer therapies.