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Leucogen-induced pemphigus foliaceus: the first case report.
Ke Gui1,2, Jingyao Liang1, Aili Gao1
1Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, China.
Frontiers in Immunology
|March 27, 2026
Summary
A rare autoimmune blistering disorder, drug-induced pemphigus (DIP), was triggered by leucogen, a non-thiol drug, in a breast cancer patient. Lesions resolved upon drug withdrawal, confirming a probable causal link.
Area of Science:
- Dermatology
- Autoimmunology
- Oncology
Background:
- Drug-induced pemphigus (DIP) is a rare autoimmune blistering disease.
- Thiol-containing drugs like penicillamine and captopril are common culprits.
- Increasing reports link non-thiol and non-phenolic drugs to DIP.

