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Exploring TGFBR3 in disease pathogenesis: Mechanisms, clinical implications, and pharmacological modulation
Hui Song1,2, Jinjiang Chou3, Peng Zhao1,4
1Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education & State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Guizhou Medical University, Guiyang, 550004, China.
Journal of Pharmaceutical Analysis
|March 27, 2026
Summary
Transforming growth factor beta receptor 3 (TGFBR3) is crucial in cell processes and disease. This review details its roles and therapeutic potential, highlighting research gaps for future strategies.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Transforming growth factor beta (TGF-β) receptor 3 (TGFBR3), also known as betaglycan, is a key transmembrane proteoglycan.
- It acts as a coreceptor for TGF-β ligands, modulating signaling pathways with context-dependent effects.
- TGFBR3's soluble isoform (sTGFBR3) antagonizes TGF-β signaling by sequestering ligands, demonstrating a dual role in pathway regulation.
Purpose of the Study:
- To provide a comprehensive review of TGFBR3's structural features and functional relevance.
- To analyze the dysregulation and molecular roles of TGFBR3 in various diseases, including cancer, neurological disorders, cardiovascular diseases, diabetes, and infectious diseases.
- To critically evaluate current experimental approaches and identify research gaps for future investigations into TGFBR3.
Main Methods:
- Systematic literature review and analysis of existing research on TGFBR3.
- Examination of structural characteristics and functional implications of TGFBR3.
- Evaluation of experimental methodologies used in TGFBR3 research.
Main Results:
- TGFBR3 significantly influences cell survival, stemness, differentiation, cancer metastasis, chemoresistance, and fibrosis.
- Dysregulation of TGFBR3 is implicated in a wide range of pathological conditions.
- Despite its importance, regulatory mechanisms like tissue-specific expression and post-translational modifications require further elucidation.
Conclusions:
- TGFBR3 is a significant biomarker and therapeutic target due to its profound influence on physiological and pathological processes.
- A deeper understanding of TGFBR3's regulatory mechanisms and disease-specific roles is essential.
- This review aims to guide the development of novel TGFBR3-targeted therapies and preclinical strategies.
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