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Related Experiment Video

Updated: Mar 28, 2026

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OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery.

Kaleigh F Roberts1,2,3, Zachary B Abrams4,3, Luca Cappelletti5

  • 1Department of Pathology & Immunology, Washington University in St. Louis, St. Louis, MO, USA.

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Summary

Agentic artificial intelligence (AI) accelerates medical discovery by automating research tasks. OpenScientist, an AI co-scientist, successfully generated novel hypotheses and insights from complex biomedical data in minutes.

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Area of Science:

  • Biomedical research
  • Artificial intelligence in medicine
  • Clinical data analysis

Background:

  • Medical discovery relies on analyzing complex data, but human time and expertise are limited.
  • Agentic artificial intelligence (AI) can automate scientific workflows, including data retrieval, analysis, and synthesis.
  • Agentic AI has the potential to accelerate scientific discovery by overcoming human limitations.

Purpose of the Study:

  • To introduce OpenScientist, an open-source agentic AI co-scientist.
  • To accelerate biomedical discovery through semi-autonomous investigation of scientist-defined queries.
  • To generate clinically relevant and verifiable scientific insights.

Main Methods:

  • OpenScientist was evaluated by domain experts in four clinical case studies.
  • Case studies included Alzheimer's disease biomarker analysis, plasma proteomic survival prediction, and neurofibrillary tangle data investigation.
  • Hypothesis generation and validation in a multiple myeloma dataset with a randomized negative control were also performed.

Main Results:

  • OpenScientist completed analyses in minutes that typically require weeks to months of human effort.
  • It identified %ptau217 as a key predictor of amyloid PET status.
  • The AI generated a plasma proteomic survival model, proposed a mechanism for tau pathology, and validated multiple myeloma hypotheses.

Conclusions:

  • Open-source, auditable agentic AI can significantly support clinical research.
  • OpenScientist demonstrates the capability to generate hypotheses and discover insights from complex datasets.
  • Agentic AI can accelerate the pace of biomedical discovery and clinical research.