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Prognostic Value of HALP Score in Rheumatic Mitral Stenosis: A Long-Term Follow-up Study

Ahmet Ferhat Kaya1, Görkem Ayhan1, Veysi Can

  • 1Department of Cardiology, Van Regional Education and Research Hospital, Van, Turkey.

Clinical Cardiology
|March 27, 2026
PubMed

Insights

The hemoglobin-albumin-lymphocyte-platelet (HALP) score shows modest prognostic value for major adverse cardiac and cerebrovascular events (MACCE) in rheumatic mitral stenosis (RMS) patients. It is a useful complementary tool but not an independent predictor alone.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Biomarkers

Background:

  • Rheumatic mitral stenosis (RMS) requires accurate prognostic tools for patient management.
  • The hemoglobin-albumin-lymphocyte-platelet (HALP) score is a composite biomarker with potential prognostic implications.

Purpose of the Study:

  • To investigate the prognostic value of the HALP score in predicting major adverse cardiac and cerebrovascular events (MACCE) in patients with RMS.

Main Methods:

  • Retrospective analysis of 169 RMS patients with a median follow-up of 124 months.
  • Assessment of HALP score's predictive performance using ROC analysis, Cox regression, and Kaplan-Meier survival analysis.
  • Primary endpoint defined as MACCE.

Main Results:

  • The HALP score demonstrated a statistically significant, albeit modest, ability to predict MACCE (AUC=0.644, p=0.037).
  • Lower HALP scores were associated with a significantly higher incidence of MACCE (log-rank p=0.015).
  • The HALP score was not an independent predictor in multivariable analysis (p=0.076).

Conclusions:

  • The HALP score can serve as a simple, cost-effective complementary tool for risk stratification in RMS patients.
  • Its prognostic value is limited when used in isolation.
  • Interpretation alongside established clinical and echocardiographic parameters is recommended.
Abstract

Keywords:
HALP scoreinflammationmajor adverse cardiac and cerebrovascular events (MACCE)nutritionprognosisrheumatic mitral stenosisrisk stratification

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