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Related Experiment Video

Updated: Jun 30, 2026

Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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A woman in her 60s with confusion

Benjamin Olofsson1, Arkady Rutkovskiy2, Ayodeji Awoyemi3

  • 1Indremedisinsk avdeling, Oslo universitetssykehus.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|March 27, 2026
PubMed
Summary
This summary is machine-generated.

Delirium in hospitalized patients can signal serious illness. This case highlights non-bacterial thrombotic endocarditis, a rare cause of stroke and organ damage, emphasizing a broad diagnostic approach for unexplained delirium.

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Area of Science:

  • Internal Medicine
  • Cardiology
  • Neurology

Background:

  • Delirium is a frequent complication in hospitalized patients, often indicating severe underlying pathology.
  • Determining the cause of delirium can be challenging, particularly when precipitating factors are not obvious.

Purpose of the Study:

  • To present a complex case of delirium with an unusual etiology.
  • To underscore the importance of a comprehensive diagnostic strategy in cases of unexplained delirium.

Main Methods:

  • A case study of a woman presenting with neurological symptoms and acute confusion.
  • Utilized blood tests, ECG, CT, MRI, PET-CT, echocardiography, and lymph node biopsy for diagnosis.
  • Investigated potential causes including infection, cardiac events, and malignancy.

Main Results:

  • The patient exhibited signs of embolic events in multiple organs (kidney, spleen, brain, myocardium).
  • Despite initial suspicion of bacterial endocarditis, malignancy (metastatic adenocarcinoma) was diagnosed.
  • Non-bacterial thrombotic endocarditis was confirmed, leading to anticoagulation therapy.

Conclusions:

  • This case illustrates non-bacterial thrombotic endocarditis as a cause of embolic phenomena and delirium.
  • A thorough and broad diagnostic workup is crucial for identifying rare causes of delirium in hospitalized patients.