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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Elevating scientific training by building a Research Alliance for Inclusive STEM Education (RAISE).

Matthew G Niepielko1,2

  • 1Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Journal of Microbiology & Biology Education
|March 27, 2026
PubMed
Summary

Fostering scientific talent through inclusive STEM education is crucial. A Research Alliance for Inclusive STEM Education (RAISE) program offers continuous research training to prepare the next generation of scientists.

Keywords:
CUREsCourse-based Undergraduate Research ExperienceSTEM educationSTEM workforce developmentexperiential learninghands-on teachinghigh school research experiencesresearch experience for undergraduatesresearch trainingscience education

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Area of Science:

  • STEM Education
  • Scientific Workforce Development
  • Research Training

Background:

  • Early identification and nurturing of student scientific talent are vital for innovation and economic growth.
  • Existing pre-college and undergraduate research programs often have limited scope and duration, hindering sustained student engagement.
  • Challenges in accessing STEM education and research training need to be addressed to build a robust scientific workforce.

Purpose of the Study:

  • To review challenges in STEM education and research training access.
  • To propose the Research Alliance for Inclusive STEM Education (RAISE) program as a solution.
  • To outline the implementation of a continuous, collaborative research training pathway.

Main Methods:

  • Review of challenges in STEM education and research training.
  • Proposal and conceptualization of the RAISE program model.
  • Outlining a multi-stage, continuous research training pathway integrated with discovery-driven projects.

Main Results:

  • RAISE integrates research and education, increasing access for diverse high school and undergraduate students.
  • The proposed RAISE pathway enables continuous skill development through a unified, multiyear research project.
  • This model addresses limitations of existing programs by offering sustained engagement opportunities.

Conclusions:

  • The RAISE program offers a scalable model for inclusive STEM education and research training.
  • Implementing RAISE programs can help resolve issues in scientific training and foster a prepared scientific workforce.
  • A call to action is issued for the development, funding, and support of RAISE initiatives.