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Updated: Mar 29, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Sulfonium Salt-Mediated Regio- and Stereoselective Aminosulfonylation of Alkynes with Sulfinates and Azoles
Sha Peng1, Jia-Xin Huang1, Le Jiang1
1College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan 425100, China.
Abstract:
In this study, a practical and efficient one-pot sulfonium salt-mediated regio- and stereoselective aminosulfonylation of alkynes with sulfinates and azoles has been established. This method enables the synthesis of structurally diverse N-heterocycle-containing (Z)-vinyl sulfones, featuring a broad substrate scope and excellent functional group tolerance. Notably, gram-scale synthesis, product derivatization, and late-stage functionalization further validate the synthetic utility of this protocol, thereby rendering it highly valuable for applications in organic synthesis and medicinal chemistry.
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