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Published on: January 30, 2015
Organophotoredox-Catalyzed Vinyl Group Transfer Reaction: An Introduction to 4-Vinyl-1,4-dihydropyridines
Akshay Kumar Mandhotra1, Suryansh Singh Aristha1, Arijit Chakraborty1
1Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab 140001, India.
None:
The visible-light-driven, organophotoredox-catalyzed vinyl group transfer reaction is described. The strategic use of proaromatic, bench-stable, and readily prepared 4-vinyl-dihydropyridine (DHP) derivatives triggers the vinyl group transfer that can couple stereoselectively with fluorinated esters and amides to forge the C(sp3)-C(sp2) bond. The obtained products are transformed into diverse fluorinated scaffolds. Preliminary mechanistic investigations are outlined.
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