Related Experiment Video
Updated: Mar 29, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Reconsidering biologic treatment recommendations for CRSwNP without asthma in EUFOREA guidelines
J Oppenheimer1, G W Canonica2, P Chanez3
1Department of Internal Medicine, University of Medicine and Dentistry of New Jersey/Rutgers New Jersey Medical School, Newark, NJ, USA.
None:
The recently published EUFOREA pocket guide "Biologics in Upper and Lower Airway Diseases" summarises recommendations on the use of biologics in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma and offers advice on biologic choice for practicing clinicians. The creation of this pocket guide, in the absence of any head-to-head studies at that time, drew on expert opinions and published indirect treatment comparison (ITC) approaches. It makes a single recommendation for a preferred biologic, in patients affected by CRSwNP, without concomitant asthma (apart from specific cases such as pregnancy), whilst offering different options in asthma endotypes and phenotypes. We wish to draw the attention of the readership to some additional considerations relating to biologic choice for these diseases and how they are classified.
Related Concept Videos
Cystic Fibrosis: Management
Sinus disease and chronic...
Drugs Used in Lower Respiratory Disorders: Overview
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
COPD: Management Using Bronchodilators and Corticosteroids
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

