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Updated: Mar 29, 2026
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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
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Dual Roles of Ubiquitin-Specific Peptidase 10 (USP10) in Cancer
Yifei Zhai1, Liming Zhou1, Manhan Zhao1
1School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang 212013, China.
Cells
|March 27, 2026
Summary
Ubiquitin-specific peptidase 10 (USP10) has dual roles in cancer, affecting tumor suppressors and oncogenes. USP10 inhibitors show promise as targeted cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Ubiquitin-specific peptidase 10 (USP10) is a deubiquitinating enzyme.
- USP10 regulates multiple signaling proteins, including tumor suppressors and oncogenes.
Purpose of the Study:
- To review the dual roles of USP10 in various cancer types.
- To discuss the association between aberrant USP10 expression and cancer development.
- To explore USP10 inhibitors as potential targeted cancer therapeutics.
Main Methods:
- Literature review of USP10's function in tumorigenesis.
- Analysis of USP10's association with specific cancer types.
- Discussion of therapeutic strategies involving USP10 inhibition.
Main Results:
- USP10 exhibits both tumor-suppressive and tumor-promoting effects.
- Aberrant USP10 expression is linked to hepatocellular carcinoma, lung, breast, prostate, gastric cancers, and leukemia.
- USP10 substrates include key proteins in cancer signaling pathways.
Conclusions:
- USP10 plays a complex, context-dependent role in cancer.
- Targeting USP10 with inhibitors represents a promising avenue for cancer treatment.
- Further research into USP10's precise mechanisms is warranted.
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