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Revisiting the Fight Against Acinetobacter baumannii: Emerging Non-Antibiotic Strategies.
Victor Hugo Montini1, Laura Santana Buso1, Pedro Henrique Takata1
1Laboratory of Basic and Applied Bacteriology, Center of Biological Sciences, Department of Microbiology, State University of Londrina, Londrina P.O. Box 10.011, Brazil.
Antibiotics (Basel, Switzerland)
|March 27, 2026
Summary
Emerging strategies combat multidrug-resistant Acinetobacter baumannii infections. This review explores novel therapies like nanotechnology, bacteriophage therapy, and drug repurposing to overcome antibiotic resistance.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Acinetobacter baumannii is a critical multidrug-resistant pathogen.
- Rising antibiotic resistance necessitates alternative therapeutic strategies.
- Conventional antibiotics are increasingly ineffective against A. baumannii.
Purpose of the Study:
- To review emerging in vitro and in vivo strategies for controlling A. baumannii.
- To provide an overview of alternative control approaches beyond conventional antibiotics.
- To highlight innovative therapeutic strategies against A. baumannii infections.
Main Methods:
- Review of current scientific literature on A. baumannii control.
- Focus on strategies disrupting metabolic pathways.
- Exploration of nanotechnology, bacteriophage therapy, and drug repurposing.
Main Results:
- Several promising adjunctive therapeutic technologies are emerging.
- Nanotechnology-based approaches show potential for targeted drug delivery.
- Bacteriophage therapy offers a biological alternative to antibiotics.
- Drug repurposing, including SSRIs, presents a viable option.
Conclusions:
- Innovative strategies are crucial for combating A. baumannii.
- A combination of approaches may be necessary for effective treatment.
- Further research is needed to translate these findings into clinical practice.
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