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Frog Skin Peptides: Nature's Dual-Action Weapons Against Infection and Cancer.

Eleonora Grisard1, Carlo Vetrano1, Ali Benour2

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Summary

Frog skin peptides show dual antimicrobial and anticancer properties, offering new therapeutic options. These natural compounds disrupt microbial membranes and target cancer cells, addressing antimicrobial resistance and cancer burden.

Keywords:
anticancer peptidesantimicrobial peptidesanuran skin secretionsapoptosisbioactive peptidesdual-function peptidesfrog skin peptidesmembrane disruptionpeptide therapeutics

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Rising antimicrobial resistance (AMR) and global cancer burden necessitate novel therapeutic approaches.
  • Frog skin secretions are a valuable source of bioactive peptides with potential therapeutic applications.

Purpose of the Study:

  • To review frog skin-derived peptides with dual antimicrobial and anticancer activities.
  • To emphasize their structural diversity, mechanisms of action, and translational potential.

Main Methods:

  • Comprehensive literature search for peptides from anuran species.
  • Analysis of studies reporting structural features, antimicrobial activity (including against MDR isolates), anticancer effects, and molecular mechanisms.

Main Results:

  • Identified peptides like dermaseptins, temporins, and brevinins possess dual functionality.
  • These peptides disrupt microbial membranes and induce cancer cell apoptosis/necrosis.
  • Key physicochemical properties (charge, amphipathicity, α-helical structure) drive dual action.

Conclusions:

  • Frog skin peptides are promising candidates for next-generation antimicrobial and anticancer therapeutics.
  • Advances in peptide engineering enhance their stability, selectivity, and clinical prospects.