Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adhesion

Adhesion

Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inhibition, biochemical activities, and control efficacy of fluopyram·tebuconazole against <i>Alternaria</i> spp. causing GALSB: Implications for QoI fungicide resistance management.

Plant disease·2026

Same author

The dual-sensitive period gut-brain crosstalk, neuroinflammation, and the biological roots of adolescent depression.

Frontiers in immunology·2026

Same author

Uncertainty Analysis of the Thermal Decomposition and Kinetic Models of Energetic Materials: A Comprehensive Overview.

Analytical chemistry·2026

Same author

Oxygen-Deficient TiO<sub>2</sub> Aerogel for Enhanced Photocatalytic Performance.

Gels (Basel, Switzerland)·2026

Same author

Editorial for the Special Issue "Gels for Removal and Adsorption (3rd Edition)".

Gels (Basel, Switzerland)·2026

Same author

Lignin-Derived N,S-Co-Doped Carbon Dots Enable Improved Mn<sub>2</sub>O<sub>3</sub> Cathodes for Aqueous Zinc-Ion Batteries.

Nanomaterials (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

Interpretable Machine Learning Insights into Adhesion and Modulus of Biomedical HA-Dopamine Hydrogels.

Yuze Zhang¹, Yabei Xu¹, Yimin Shi²

¹Key Laboratory of Bio-Based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.

Gels (Basel, Switzerland)

|March 27, 2026

Summary

This study uses machine learning to understand how hyaluronic acid-dopamine (HA-Dopa) hydrogel properties relate to their formulation. This helps optimize these promising biomaterials for medical uses.

Keywords:

biomedical materials hyaluronic acid machine learning

More Related Videos

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

Related Experiment Videos

Last Updated: Mar 29, 2026

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

An Optimized O9-1/Hydrogel System for Studying Mechanical Signals in Neural Crest Cells

Published on: August 13, 2021

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

Area of Science:

Biomaterials Science
Polymer Chemistry
Computational Biology

Background:

Hyaluronic acid-dopamine (HA-Dopa) hydrogels show potential for biomedical applications due to their adhesive properties.
Complex formulation-performance relationships hinder rational design of HA-Dopa hydrogels.

Purpose of the Study:

To develop an interpretable machine learning framework to investigate structure-property relationships in HA-Dopa hydrogels.
To identify key formulation parameters influencing HA-Dopa hydrogel adhesion and mechanical properties.

Main Methods:

Collected a dataset of 228 data points from 37 peer-reviewed publications.
Developed gradient boosting regression models to predict adhesion strength and elastic modulus.
Utilized SHAP analysis to interpret model predictions and identify dominant features.

Main Results:

Achieved high prediction accuracy for adhesion strength (R²=0.99) and elastic modulus (R²=0.94).
Identified hyaluronic acid molecular weight and dopamine substitution degree as primary drivers of adhesion.
Observed a more distributed dependence of mechanical properties on multiple formulation parameters.

Conclusions:

Interpretable machine learning effectively elucidates structure-property relationships in HA-Dopa hydrogels.
Findings provide guidance for optimizing HA-Dopa hydrogel formulations for targeted biomedical applications.
This approach accelerates the development of advanced functional hydrogels.