Alginate-Based Biomaterials: From Fundamental "Egg-Box" Chemistry to Diverse Biomedical and Metabolic Management of...

Alginate, a naturally occurring polysaccharide derived from brown algae, has emerged as a versatile cornerstone in the field of biomedical materials. Its widespread adoption is driven by its exceptional biocompatibility and the unique cation-dependent gelation defined by the "egg-box" model. This review examines the fundamental chemistry of alginate, detailing how its crosslinking mechanisms dictate the physicochemical properties essential for clinical performance. The discussion bridges the gap between polymer structure and diverse biomedical applications, including drug delivery, tissue engineering, and the clinical management of gastrointestinal reflux and wound care. Furthermore, the article evaluates the role of alginate-based systems in the biomedical and metabolic management of obesity and diabetes. By analyzing how alginate influences satiety, glycemic index modulation, and lipid absorption through biophysical mechanisms, this review highlights the transition from fundamental chemical architecture to practical clinical utility. By integrating structural chemistry with physiological impact, this work underscores the evolving potential of alginate-based materials as supportive and functional strategies in modern clinical care.