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Performance-based Functional Status Predicts Diffuse Cortical Atrophy In Alzheimer's Disease.

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Performance-based Functional Status Predicts Diffuse Cortical Atrophy In Alzheimer's Disease.

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Performance-Based Functional Status Predicts Diffuse Cortical Atrophy in Alzheimer's Disease.

Renata Kochhann^1,2, Patricia Ferreira da Silva¹, Eelco van Duinkerken^3,4

¹Psychology Department, Post-Graduate Program in Psychology, Human Cognition, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, Brazil.

|March 27, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Performance-based functional ability, measured by the Direct Assessment of Functional Status-Revised (DAFS-R), is a stronger indicator of cortical thickness than cognitive screening or proxy-evaluated function in elders. This finding highlights DAFS-R

Keywords:

activities of daily living brain cortical thickness cognition dementia

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

Neuroimaging
Cognitive Neuroscience
Geriatrics

Background:

Cognitive impairment and dementia significantly impact functional ability.
Understanding the relationship between brain structure and function is crucial for early detection and intervention.
Cortical thickness is a key neuroimaging biomarker for neurodegenerative diseases.

Purpose of the Study:

To compare performance-based functional ability and cognitive screening performance in relation to cortical thickness.
To compare performance-based and proxy-evaluated functional ability and their cerebral white and gray matter correlates.
To investigate the association between different measures of functional ability and cortical thickness in cognitively unimpaired elders, mild cognitive impairment (MCI), and dementia patients.

Main Methods:

Inclusion of 22 cognitively unimpaired (CN), 32 MCI, and 21 dementia patients.
Utilized Magnetic Resonance Imaging (MRI) for brain assessment.
Administered Mini-Mental State Examination (MMSE), Rey Auditory Verbal Learning test (RAVLT), Activities of Daily Living Questionnaire (ADL-Q), and Direct Assessment of Functional Status-Revised (DAFS-R).

Main Results:

Higher ADL-Q scores correlated with reduced cortical thickness in temporoparietal regions.
DAFS-R scores showed a relationship with greater cortical thickness across frontal, parietal, and temporal cortices.
MMSE scores were focally associated with medial and lateral temporal and inferior parietal regions.

Conclusions:

Functional independence (ADL-Q) is linked to frontal and parietal cortical thickness.
DAFS-R scores provide a more diffuse measure of cortical atrophy.
Performance-based functional abilities (DAFS-R) are stronger markers of cortical thickness than ADL-Q and MMSE.