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An Augmented Reality-Based Navigation System for Stereotactic Brain Biopsy with Multi-Objective Path Planning and
Tao Zhang1, Shuyi Wang1, Yueyang Zhong1
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Brain Sciences
|March 27, 2026
Summary
This study introduces an augmented reality navigation system for stereotactic brain biopsy, improving surgical path planning and accuracy. The system enhances procedural safety and consistency in neurosurgery.
Area of Science:
- Neurosurgery
- Medical Technology
- Computer-Aided Surgery
Background:
- Stereotactic brain biopsy is crucial for diagnosing malignant brain tumors.
- Conventional methods face challenges with manual path planning and navigation, increasing complication risks and surgeon burden.
Purpose of the Study:
- To develop and evaluate an augmented reality (AR)-based navigation system for stereotactic brain biopsy.
- To enhance surgical precision and safety through automated path planning and real-time guidance.
Main Methods:
- Developed an AR navigation system integrating multi-objective optimization (MOO) for automated path planning.
- Employed a hybrid registration technique using QR codes and anatomical landmarks for accurate intraoperative alignment.
- Enabled real-time overlay of surgical paths and anatomical models onto the patient's operative field.
Main Results:
- The MOO model significantly improved safety criteria compared to manual methods.
- Hybrid registration reduced mean fiducial registration error (FRE) from 4.19 mm to 2.37 mm (p < 0.001).
- Achieved a mean target registration error (TRE) of 2.34 mm and a mean setup time of 2.63 minutes.
Conclusions:
- The AR system facilitates stereotactic brain biopsy with automated planning and immersive guidance.
- The technology shows potential for improving surgical workflow consistency and patient safety in neuro-oncology.
