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Updated Conversion Table for the Multiple Criteria Qualitative Value-Based Pricing Framework "MARIE".

Akina Takami¹, Ataru Igarashi¹

¹Department of Health Policy and Public Health, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Tokyo 113-0033, Japan.

Journal of Market Access & Health Policy

|March 27, 2026

Summary

The MARIE method uses a conversion table to determine new drug prices based on value. Updating this table with current drug prices ensures continuity and supports the social implementation of value-based drug pricing.

Keywords:

drug pricing economics methodology pharmacoeconomics regulation regulatory science value-based pricing

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Area of Science:

Health Economics
Pharmaceutical Policy

Background:

Value-based pricing aims for appropriate healthcare expenditure allocation.
The MARIE (Measuring Added value and REward in pricing) method qualitatively assesses drug value without comparators.
This study focused on updating the MARIE method's conversion table for monetizing drug value points.

Purpose of the Study:

To update the conversion table used in the MARIE method for drug pricing.
To maintain continuity with Japan's current drug pricing system.
To support the social implementation of the MARIE method.

Main Methods:

Collected daily drug prices at listing for new active ingredient drugs (FY2015-2024) from Japan's National Health Insurance Drug Price List.
Utilized descriptive statistics to analyze the collected drug pricing data.
Updated the conversion table based on current drug prices.

Main Results:

The conversion table was updated using recent drug pricing data to ensure continuity.
A trend was observed where lower maximum patient numbers correlated with higher median daily drug prices.
Annual updates to new drug prices in Japan necessitate ongoing adjustments to the conversion table.

Conclusions:

The MARIE method, with its updated conversion table, is crucial for qualitatively evaluating drug value and monetizing it.
Regularly updating the conversion table with the latest drug pricing data ensures alignment with the current system.
The updated MARIE method framework contributes to the practical application of value-based drug pricing in society.