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Gold-Catalyzed Regioselective Remote B(9)-H Activation of o-Carboranes with Silylenynones: Access to
Yue Hao1, Huiyuan Zheng1, Chengrui Hang1
1School of Chemistry and Chemical Engineering, Ludong University, Yantai 264025, China.
Abstract:
The gold-catalyzed regioselective remote B(9)-H functionalization of o-carboranes through regioselective insertion of α-furyl silyl gold carbenes generated from silylenynones into the B(9)-H bond of o-carboranes offers facile and atom-economical access to various B(9)-α-furylsilyl-o-carboranes in moderate to good yields (up to 88%) with excellent regioselectivities. This method can also be expanded to the selective B-H functionalization of m-carboranes. The synthetic potential of this methodology is exemplified by gram-scale experiments and synthetic transformations of the products.
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